James N. Topper, M.D., Ph.D.

Managing Partner

Jamie co-leads Frazier’s Life Sciences team and has over 25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies.

Jamie is a Managing Partner of Frazier Healthcare Partners' Life Sciences team. He joined Frazier in 2003 and opened Frazier’s Menlo Park office in the same year. Throughout his 16 years as a Managing Partner, Jamie has invested across over 35 companies encompassing a broad spectrum of Life Science and Biopharmaceutical companies.

Jamie has led many of Frazier’s successful life sciences investments, including Acerta Pharma BV (sold to AstraZeneca), Amunix Pharmaceuticals (sold to Sanofi), Calistoga Pharmaceuticals (co-founder, sold to Gilead Sciences), Mavupharma (sold to AbbVie), Rempex (sold to The Medicines Company), Incline (co-founder, sold to The Medicines Company), Alnara (sold to Lilly), Portola (co-founder, NASDAQ: PTLA), CoTherix (sold to Actelion), and Threshold (NASDAQ: THLD). He currently represents Frazier on the boards of Alpine Immune Sciences (NASDAQ: ALPN), AnaptysBio (NASDAQ: ANAB), Lassen Therapeutics, NewAmsterdam Pharma (NASDAQ: NAMS), Phathom Pharmaceuticals (NASDAQ: PHAT), and Seraxis. In addition, Jamie is a board observer for Alcresta Therapeutics. He previously served as Chairman and Chief Executive Officer of Frazier-sponsored SPAC Frazier Lifesciences Acquisition Corporation.

Prior to joining Frazier, Jamie was the head of cardiovascular R&D at Millennium Pharmaceuticals and ran Millennium San Francisco (formerly COR Therapeutics). Before the merger of COR and Millennium, he served as the Vice President of Biology at COR and was responsible for all research activities. He served on the medical school faculties at Stanford and Harvard Medical School prior to joining COR.

Jamie received his M.D. and Ph.D. in Biophysics from Stanford and holds a B.S. from the University of Michigan. He did his postgraduate training in Internal Medicine and Cardiovascular Disease at the Brigham and Women's Hospital in Boston. He has authored over 50 publications and was the recipient of a Howard Hughes Scholars Award while on the faculty at Stanford.

In 2011 and 2016 Jamie was named to the Midas List of leading venture capitalists, and in 2013 was recognized by Forbes as one of the top 10 healthcare investors.

Menlo Park

University of Michigan (B.S.)
Stanford University (M.D., Ph.D.)

Year Joined